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Updated: May 24, 2026

Imine Metathesis by Silica-Supported Catalysts Using the Methodology of Surface Organometallic Chemistry
Published on: October 18, 2019
Scandium(III)-zeolites as new heterogeneous catalysts for imino-Diels-Alder reactions
Andrea Olmos1, Benoit Louis, Patrick Pale
1Institute of Chemistry, UMR 7177, Université de Strasbourg, 4 rue B. Pascal, 67000 Strasbourg, France.
Abstract:
This study demonstrates the first zeolite-catalyzed synthesis of piperidine derivatives, including peptidomimetics and indoloquinolizidine alkaloids. The approach developed utilizes a highly effective one-pot reaction cascade, through imine formation and imino-Diels-Alder reactions, promoted by scandium-loaded zeolites as a heterogeneous catalyst. The methodology described benefits from very low catalyst loadings (≤5 mol % of Sc(III) ), commercially and readily available starting materials, and mild reaction conditions. Furthermore, the Sc(III) -zeolite catalyst can be readily reused more than 10 times without any loss in efficiency.
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