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Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

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Related Experiment Video

Updated: May 24, 2026

Soft Pneumatic Robot Modulates Graph Theory Metrics of Brain Network for Hand Rehabilitation After Stroke
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Soft Pneumatic Robot Modulates Graph Theory Metrics of Brain Network for Hand Rehabilitation After Stroke

Published on: October 10, 2025

Functional connectivity and neurological recovery.

Maurizio Corbetta1

  • 1Washington University School of Medicine, Saint Louis, MO 63110, USA. mau@npg.wustl.edu

Developmental Psychobiology
|March 15, 2012
PubMed
Summary

Brain networks and synchronized activity are key to cognition. Disruptions in resting-state network coherence after brain injury correlate with behavioral deficits and recovery.

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Systems Neuroscience

Background:

  • Modern brain function theories emphasize distributed networks and synchronized activity.
  • Brain-behavior relationships after focal lesions involve both local damage and widespread network alterations.
  • Coherent activity in large-scale brain networks occurs during tasks and at rest.

Purpose of the Study:

  • To investigate the role of network coherence in brain function and injury.
  • To understand how resting-state network activity relates to behavioral deficits and recovery after brain injury.

Main Methods:

  • Analysis of large-scale brain network activity.
  • Correlation of network coherence with behavioral outcomes.
  • Examination of resting-state brain activity.

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Motor Imagery Brain-Computer Interface in Rehabilitation of Upper Limb Motor Dysfunction After Stroke

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Soft Pneumatic Robot Modulates Graph Theory Metrics of Brain Network for Hand Rehabilitation After Stroke
05:30

Soft Pneumatic Robot Modulates Graph Theory Metrics of Brain Network for Hand Rehabilitation After Stroke

Published on: October 10, 2025

Motor Imagery Brain-Computer Interface in Rehabilitation of Upper Limb Motor Dysfunction After Stroke
09:42

Motor Imagery Brain-Computer Interface in Rehabilitation of Upper Limb Motor Dysfunction After Stroke

Published on: September 1, 2023

Main Results:

  • Coherent activity is observed in brain networks during rest, not just during tasks.
  • Breakdown of coherent activity at rest, even in intact regions, correlates with behavioral deficits.
  • Changes in network coherence are linked to functional recovery after brain injury.

Conclusions:

  • A network perspective is crucial for understanding healthy brain function.
  • This network approach is fundamental to understanding brain injury pathophysiology and recovery.
  • Network analysis provides a basis for novel therapeutic interventions for brain injuries.