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[Genetic performance criteria for valproate in patients with epilepsy]
Abstract:
We found a clear correlation between the presence of the CC genotype and genotype combination CC and CT P-glycoproteins rs1045642 and rs1128503 with farmakorezystentnistyu data of patients with valproate (P < 0,01). Also, based on studies demonstrated that the presence of polymorphism TT P-glycoproteins rs1045642 is a positive criterion of forecast performance valproate in a particular patient with epilepsy. We use the definition of P-glycoproteins SNPs rs1045642 and rs1128503 to accelerate the selection of adequate antiepileptic that reduces the selection of adequate treatment tactics in a particular patient. This in turn will prevent the development epileptohenezu that increase the likelihood of full kurabelnosti patient.
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