Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gastric cancer surgery in the era of neoadjuvant immunotherapy.

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu·2026
Same author

Gibberellic Acids and ethylene antagonistically regulate stem growth via SlGAI-SlERF1B-SlXTH19 module in tomato.

Plant physiology·2026
Same author

Reply to McDannell et al.: Thermal overprinting does not obscure the tectonic origin of the Great Unconformity.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Decoding cryptic defluorinases through a latent generative sequence landscape.

Chemical science·2026
Same author

Perioperative serplulimab with neoadjuvant chemotherapy versus perioperative chemotherapy in PD-L1-positive gastric cancer (ASTRUM-006): a randomised, double-blind, multicentre, phase 3 study.

Lancet (London, England)·2026
Same author

Residual Content Impacts Critical Quality Attributes and Performance of Risperidone Microspheres.

Pharmaceutical research·2026

Related Experiment Video

Updated: May 24, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

Single nucleotide polymorphisms analysis of noise-induced hearing loss using three-dimensional polyacrylamide

Guihua Xia1, Weiwei Gao, Ke Ji

  • 1Department of Otolaryngology, Beilun Branch of the First Affiliated Hospital (People's Hospital of Beilun), Medical College of Zhejiang University, Ningbo 315800, China.

Journal of Biomedical Nanotechnology
|March 16, 2012
PubMed
Summary

This study identified three single nucleotide polymorphisms (SNPs) that increase susceptibility to noise-induced hearing loss (NIHL) in Chinese industrial workers. These findings highlight the genetic component of NIHL in this population.

More Related Videos

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
07:13

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
10:01

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform

Published on: September 27, 2016

Related Experiment Videos

Last Updated: May 24, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
07:13

Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Published on: February 10, 2023

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
10:01

The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform

Published on: September 27, 2016

Area of Science:

  • Occupational Health
  • Genetics
  • Audiology

Background:

  • Noise-induced hearing loss (NIHL) is a significant occupational hazard affecting millions of industrial workers, particularly in China.
  • While environmental noise exposure is a known risk factor, the genetic predispositions contributing to NIHL remain unclear.
  • Understanding genetic susceptibility is crucial for developing targeted prevention strategies for NIHL.

Purpose of the Study:

  • To investigate the association between specific genetic variations (SNPs) and susceptibility to NIHL in Chinese noise-exposed workers.
  • To identify candidate genes and their polymorphisms that may confer risk for developing NIHL.
  • To analyze the interaction between noise exposure levels and genetic factors in the development of NIHL.

Main Methods:

  • Genotyping of 15 single nucleotide polymorphisms (SNPs) within 6 candidate genes using 3D polyacrylamide gel-based microarray platforms.
  • Collection of 103 blood samples from noise-exposed laborers in Ningbo, Zhejiang, China.
  • Logistic regression analysis to evaluate the interaction between noise exposure and genotypes on NIHL risk.

Main Results:

  • The study identified three specific SNPs that showed a significant association with NIHL risk in noise-exposed Chinese workers.
  • These SNPs, in interaction with noise exposure levels, were confirmed as susceptibility factors for NIHL.
  • The findings provide evidence for a genetic component influencing individual susceptibility to noise-induced hearing damage.

Conclusions:

  • Specific genetic polymorphisms play a role in determining an individual's susceptibility to noise-induced hearing loss.
  • The identified SNPs represent potential biomarkers for predicting NIHL risk in Chinese populations.
  • Further research into these genetic factors can inform personalized prevention and management strategies for occupational hearing loss.