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11:09
EPA Method 1615. Measurement of Enterovirus and Norovirus Occurrence in Water by Culture and RT-qPCR. II. Total Culturable Virus Assay
Published on: September 11, 2016
Non-polio enteroviruses serotypes circulating in Nigeria
1Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
African Journal of Medicine and Medical Sciences
|March 16, 2012
Summary
This study identified diverse non-polio enterovirus (NPEV) serotypes in Nigerian children, revealing significant circulation of HEV-B species. The findings highlight the ongoing risk of acute flaccid paralysis (AFP) even after polio eradication due to neurotropic NPEVs.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Enteroviruses are common human pathogens causing diverse acute illnesses.
- Despite global polio eradication, other enterovirus infections remain a significant health concern, particularly in children.
- Non-polio enteroviruses (NPEVs) pose a continuous threat, necessitating ongoing surveillance.
Purpose of the Study:
- To determine the circulating serotypes of NPEVs in Nigerian children.
- To understand the molecular epidemiology of NPEVs in Nigeria for the first time.
- To assess the potential link between identified NPEVs and diseases like acute flaccid paralysis (AFP).
Main Methods:
- Collection of stool samples from hospitalized children and AFP cases across Nigeria.
- Presumptive identification of NPEVs using RD cell culture.
- Serotype identification via neutralization assays and confirmed by genotypic methods (PCR).
Main Results:
- Neutralization assay identified echoviruses (43.5%), coxsackie B viruses (29.7%), and untypeable isolates (26.8%).
- Genotyping confirmed specific echovirus, coxsackievirus, and enterovirus serotypes, with a majority belonging to the human enterovirus B (HEV-B) species.
- Causal associations between isolates and various diseases were established, including neurotropic serotypes linked to AFP.
Conclusions:
- This study establishes the molecular epidemiology of NPEVs in Nigeria.
- The presence of neurotropic NPEV serotypes indicates a continued risk of AFP post-polio eradication.
- Findings underscore the importance of continued surveillance and control of NPEV infections in Nigeria.
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