Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 24, 2026

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

Lymph node count threshold for optimal pelvic lymph node staging in prostate cancer.

Firas Abdollah¹, Maxine Sun, Rodolphe Thuret

¹Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Centre, Montreal, Quebec, Canada. firas.abdollah@gmail.com

International Journal of Urology : Official Journal of the Japanese Urological Association

|March 16, 2012

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Obesity is associated with biochemical recurrence after radical prostatectomy: A multi-institutional extended validation study.

Urologic oncology·2017

Same author

An Explanatory Case on the Limitations of Lymph Node Staging in Recurrent Prostate Cancer.

Urology case reports·2017

Same author

Diagnostic Accuracy of <sup>64</sup>Copper Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography for Primary Lymph Node Staging of Intermediate- to High-risk Prostate Cancer: Our Preliminary Experience.

Urology·2017

Same author

The Microbiome of the Prostate Tumor Microenvironment.

European urology·2017

Same author

Is transurethral resection alone enough for the diagnosis of histological variants? A single-center study.

Urologic oncology·2017

Same author

Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Primary Non-muscle-invasive Bladder Cancer.

Clinical genitourinary cancer·2017

Removing at least 20 lymph nodes during prostate cancer surgery ensures accurate staging of lymph node metastases. This extended pelvic lymph node dissection improves staging accuracy to 90% across all tumor risk groups.

Area of Science:

Urology
Oncology
Surgical Pathology

Background:

Pelvic lymph node dissection (PLND) is crucial for staging prostate cancer.
The optimal number of lymph nodes to remove for accurate staging remains debated.

Purpose of the Study:

To determine the relationship between the extent of PLND and lymph node metastasis rates.
To identify the ideal number of lymph nodes for optimal prostate cancer staging.

Main Methods:

Analysis of 20,789 prostate cancer patients undergoing radical prostatectomy and PLND (2004-2006).
Receiver operating characteristic (ROC) analyses to assess staging accuracy based on lymph node count.
Univariable and multivariable regression to evaluate lymph node count's impact on metastasis rates.

More Related Videos

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

Related Experiment Videos

Last Updated: May 24, 2026

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

Main Results:

Average lymph node count was 6.4 (median 5.0); overall metastasis rate was 2.5%.
Metastasis rates were 0.2% (low), 1.5% (intermediate), and 6.7% (high-risk tumors).
Removing 20 lymph nodes achieved a 90% probability of correct staging, irrespective of tumor risk.

Conclusions:

A higher lymph node yield correlates with improved staging accuracy.
Extended PLND, removing at least 20 lymph nodes, is recommended for 90% accurate staging.
This approach necessitates an anatomically extended dissection technique.