Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pulmonary Embolism I: Introduction

Pulmonary Embolism I: Introduction

A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...

Pulmonary Embolism I: Introduction

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...

Pulmonary Embolism III: Nursing Management

Pulmonary Embolism III: Nursing Management

A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

2021 Canadian Surgery Forum: Virtual, online Sept. 21-24, 2021.

Canadian journal of surgery. Journal canadien de chirurgie·2022

Same author

Combined small-cell lung carcinoma revealed to be an intratumoural metastasis by genetic analysis.

Annals of oncology : official journal of the European Society for Medical Oncology·2021

Same author

The prospective Hemophilia Inhibitor PUP Study reveals distinct antibody signatures prior to FVIII inhibitor development.

Blood advances·2020

Same author

Cardiac adaptation in asphyxiated infants treated with therapeutic hypothermia.

Journal of neonatal-perinatal medicine·2019

Same author

Factors associated with the orthopaedic surgeon's decision to recommend total joint replacement in hip and knee osteoarthritis: an international cross-sectional study of 1905 patients.

Osteoarthritis and cartilage·2018

Same author

Pharmacokinetics and the transition to extended half-life factor concentrates: communication from the SSC of the ISTH.

Journal of thrombosis and haemostasis : JTH·2018

Search research articles

Related Experiment Video

Updated: May 24, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Pulmonary embolism in sickle cell disease: a case-control study.

E M Novelli¹, C Huynh, M T Gladwin

¹Department of Medicine, Division Hematology/Oncology, University of Pittsburgh, Pittsburgh, PA 15213-4306, USA.

Journal of Thrombosis and Haemostasis : JTH

|March 16, 2012

Summary

Pulmonary embolism (PE) occurs more often in hospitalized patients with sickle cell disease (SCD). Lower chest CT use in SCD patients suggests PE may be underdiagnosed.

Related Experiment Videos

Last Updated: May 24, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Area of Science:

Hematology
Pulmonology
Critical Care Medicine

Background:

Pulmonary embolism (PE) is a significant cause of mortality in hospitalized individuals.
The prevalence of PE in sickle cell disease (SCD) and its association with disease severity or hypercoagulability remain unclear.

Purpose of the Study:

To determine the incidence and prevalence of inpatient PE in SCD patients compared to non-SCD patients.
To investigate the relationship between PE, disease severity, and mortality in SCD.

Main Methods:

Utilized Pennsylvania Health Care Cost Containment Council (PHC4) discharge data (2001-2006) to estimate PE incidence and prevalence.
Conducted a case-control study using University of Pittsburgh Medical Archival Records System (MARS) data to assess PE risk factors.

Main Results:

Inpatient PE incidence was higher in the SCD population than the non-SCD population.
SCD patients with PE were older, had longer hospital stays, greater illness severity, and higher mortality.
Chest computed tomography (CT) utilization was lower in SCD patients with PE compared to non-SCD patients with PE.

Conclusions:

The incidence of PE is elevated in hospitalized SCD patients.
Lower chest CT utilization in SCD patients suggests potential underdiagnosis of PE.
Further research is needed to understand PE risk factors and improve diagnostic strategies in SCD.