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Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice
15:45

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Published on: February 10, 2013

Rest left ventricular function and contractile reserve by dobutamine stress echocardiography in peripartum

Marcia M Barbosa1, Cláudia M V Freire, Bruno Ramos Nascimento

  • 1ECOCENTER, Hospital Socor, Belo Horizonte, MG, Brazil.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|March 16, 2012
PubMed

Insights

Left ventricular ejection fraction at baseline predicts recovery in peripartum cardiomyopathy patients. Dobutamine stress echocardiography did not predict recovery, and myocardial fibrosis was uncommon in this study.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Reproductive Medicine

Background:

  • Peripartum cardiomyopathy (PPCM) is a rare form of heart failure.
  • Predicting left ventricular functional recovery in PPCM is crucial for patient management.
  • Dobutamine stress echocardiography (DSE) and cardiac magnetic resonance imaging (MRI) are imaging modalities used in cardiology.

Purpose of the Study:

  • To evaluate if contractile reserve during DSE predicts left ventricular functional recovery in PPCM patients.
  • To assess the presence of myocardial fibrosis using MRI in PPCM patients.
  • To identify predictors of functional recovery in PPCM.

Main Methods:

  • Nine patients with PPCM underwent DSE and MRI.
  • Follow-up included rest Doppler echocardiography at six months.
  • Correlation between baseline parameters, DSE response, and recovery was analyzed.

Main Results:

  • Eight of nine patients experienced left ventricular functional recovery.
  • Baseline left ventricular ejection fraction, but not DSE response, predicted recovery.
  • Myocardial fibrosis was detected in only one patient.

Conclusions:

  • Baseline left ventricular ejection fraction is a predictor of recovery in PPCM.
  • DSE is not a reliable predictor of recovery in PPCM.
  • Myocardial fibrosis is infrequent in PPCM.
Abstract

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