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Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers
Published on: May 5, 2016
Easily fabricated, robust fiber-optic probe for weak fluorescence detection: modeling and initial experimental
Jianjun Ma1, Yasser Chiniforooshan, Wenhui Hao
1Centre de recherche en photonique, Département d’informatique et d’ingénierie, Université du Québec en Outaouais, P. O. Box 1250, Hull Station, Gatineau, Québec J8X 3X7, Canada. ma.jianjun@uqo.ca
Optics Express
|March 16, 2012
Summary
This study presents an optimized fiber-optic probe design for detecting low quantum yield fluorophores. The improved probe successfully detects weak polymer fluorescence, enabling sensitive measurements.
Area of Science:
- Optics and Photonics
- Materials Science
- Biomedical Engineering
Background:
- Detecting fluorescence from low quantum yield materials is difficult with fiber-optic probes.
- Inexpensive and robust probe designs are needed for practical applications.
Purpose of the Study:
- To develop a theoretical model for optimizing fiber-optic probe designs.
- To enhance the fluorescence-capture capability of bifurcated/coaxial probes.
- To experimentally validate the probe's performance with low quantum yield fluorophores.
Main Methods:
- Development of a theoretical model to guide probe optimization.
- Experimental construction and testing of an optimized bifurcated/coaxial fiber-optic probe.
- Measurement of fluorescence from a polymer fluorophore with a low quantum yield (0.0065).
Main Results:
- The theoretical model provided a straightforward approach to optimize probe design.
- An optimized fiber-optic probe demonstrated successful detection of weak fluorescence.
- The probe achieved detection of a polymer fluorophore with a quantum yield of 0.0065.
Conclusions:
- Optimized fiber-optic probes can effectively detect low quantum yield fluorophores.
- The proposed theoretical model aids in designing sensitive and robust fiber-optic sensing systems.
- This work advances capabilities in optical sensing for challenging fluorescent materials.
