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Published on: October 22, 2020
Effects of exercise on systemic inflammatory, coagulatory, and cardiac autonomic parameters in an inhalational
Aneesh Donde1, Hofer Wong, Jessica Frelinger
1Human Exposure Laboratory, Division of Occupational and Environmental Medicine, University of California San Francisco, San Francisco, CA, USA.
Background:
Intermittent moderate-intensity exercise is used in human inhalational exposure studies to increase the effective dose of air pollutants.
Objective:
To investigate the inflammatory, coagulatory, and autonomic effects of intermittent moderate-intensity exercise.
Methods:
We measured hemodynamic, electrocardiographic, inflammatory, and coagulatory parameters in peripheral blood of 25 healthy subjects across an exercise protocol that included running on a treadmill or pedaling a cycle ergometer for 30 minutes every hour over 4 hours in a climate-controlled chamber with a target ventilation of 20 L/min/m2 body surface area.
Results:
Intermittent moderate-intensity exercise induced a systemic proinflammatory response characterized by increases in leukocyte counts, C-reactive protein, monocyte chemoattractant protein-1, and interleukin-6, but did not change coagulation tendency or heart rate variability.
Conclusion:
Interpretation of pollutant-induced inflammatory responses in inhalational exposure studies should account for signals and noises caused by exercise, especially when the effect size is small.
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