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Updated: May 24, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Utility of desensitisation for allergy to antibiotics
H de Groot1, W M C Mulder, I Terreehorst
1Department of Pediatric Allergology, Diaconessenhuis Voorburg, RdGG, Delft, the Netherlands. grooth@rdgg.nl
Abstract:
Immediate-type allergic reactions to medication are potentially life threatening and can hamper the drug therapy of several medical conditions. If no alternative drug treatment is available, a desensitisation procedure may secure the continuation of necessary therapy by inducing a temporal state of tolerance. Desensitisation is only appropriate in case of a strong suspicion of an IgE-mediated allergic reaction. It should be performed by trained clinicians (allergy specialists) in a hospital setting where treatment of a potential anaphylactic reaction can be done without any delay. In this article, literature describing desensitisation procedures for several antibiotics is reviewed.
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