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Updated: May 24, 2026
08:12
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
Translation initiation in colorectal cancer
Armen Parsyan1, Greco Hernández, Sarkis Meterissian
1Department of Surgery, McGill University, Montreal, Canada. armen.parsyan@mail.mcgill.ca
Cancer Metastasis Reviews
|March 16, 2012
Summary
Deregulation of translation initiation is a key factor in colorectal cancer (CRC) development. Targeting this process offers new therapeutic strategies for improving CRC treatment outcomes.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Colorectal cancer (CRC) remains a significant cause of mortality globally.
- While screening improves early detection, novel treatment strategies for CRC are essential.
- Emerging research highlights the protein synthesis machinery's role in cancer.
Purpose of the Study:
- To explore the role of translation initiation in colorectal cancer (CRC) pathogenesis.
- To summarize current and future therapeutic strategies targeting translation initiation in CRC.
Main Methods:
- Review of current literature on protein synthesis, translation initiation, and CRC.
- Analysis of the molecular mechanisms linking translation initiation to cancer development.
Main Results:
- Dysregulation of translation initiation is increasingly recognized as critical in CRC growth and progression.
- Targeting specific components of the translation initiation process shows promise for CRC therapy.
Conclusions:
- Translation initiation is a fundamental process implicated in colorectal cancer.
- Inhibiting translation initiation represents a promising avenue for novel CRC treatments.
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01:31Translation
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
01:31Translation
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
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First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...