Related Experiment Video
Updated: May 24, 2026
10:45
Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
Published on: June 13, 2018
[Skin and soft tissue infections]
1Medizinische Klinik, Kantonsspital Olten. jpiso_ol@spital.ktso.ch
Praxis
|March 16, 2012
Summary
Skin and soft tissue infections (SSTIs) are common. This review covers frequent pathogens, diagnostic approaches, and treatment strategies for challenging cases like recurrent infections and diabetic foot ulcers.
Area of Science:
- Infectious Diseases
- Dermatology
- Microbiology
Context:
- Skin and soft tissue infections (SSTIs) represent a significant clinical challenge in both hospital and outpatient settings.
- Effective management necessitates understanding prevalent pathogens and tailored diagnostic and therapeutic strategies.
- Acute SSTIs are generally manageable, but chronic or recurrent forms pose considerable difficulties.
Purpose:
- To provide a comprehensive overview of common pathogens implicated in SSTIs.
- To outline current diagnostic procedures and treatment principles for SSTIs.
- To address the complexities in managing challenging SSTI cases, including recurrent furunculosis, chronic wounds, and diabetic foot infections.
Summary:
- SSTIs are frequent, requiring focus on common causative agents.
- Acute infections are typically straightforward, unlike chronic conditions.
- Recurrent furunculosis, chronic wounds, and diabetic foot infections present significant management challenges.
Impact:
- Improved understanding of SSTI pathogens and management.
- Enhanced treatment strategies for difficult-to-treat SSTIs.
- Better patient outcomes and reduced physician frustration in managing chronic SSTIs.
Related Concept Videos
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:29Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
01:27The Skin Microbiota
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
01:27Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
01:26Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
01:26Defense Mechanism Against Infection
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...