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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
Published on: February 8, 2018
The immune contexture in human tumours: impact on clinical outcome
Wolf Herman Fridman1, Franck Pagès, Catherine Sautès-Fridman
1INSERM UMRS872, Laboratory of Immune microenvironment and tumours, Paris F75006, France.
Abstract:
Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels, cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating immune cells have different effects on tumour progression, which can vary according to cancer type. In this Opinion article we discuss how the context-specific nature of infiltrating immune cells can affect the prognosis of patients.
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