Related Experiment Video
Updated: May 24, 2026
High-resolution Tandem Mass Spectrometry for Studying Chemical Constituents of Gynura bicolor DC
Published on: February 2, 2024
[Screening and identifying hepatotoxic components in Aucklandiae Radix with GC-MS]
Xiao-ping Zhao1, Lin Lu, Bin Hu
1Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. zhaoxiaoping8686@sina.com
Objective:
To screen the potential hepatotoxic components in Chinese herb medicine Aucklandiae Radix.
Methods:
The potential hepatotoxic components were screened using HepG2 cells labeled with fluorescein diacetate from 25 fractions of Aucklandiae Radix, in which the hepatotoxic compounds were further identified with GC-MS.
Results:
Ten potential hepatotoxic fractions were screened. The identification results by GC-MS indicated that the main compounds in C09 were dehydrocostuslactone, santamarine (or magnolialide) and reynosin, and in C11 were α-costol and elemol.
Conclusion:
Dehydrocostuslactone, santamarine (or magnolialide), reynosin, α-costol and elemol are potential hepatotoxic compounds in Aucklandiae Radix.
