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Related Experiment Video

Updated: May 24, 2026

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

Published on: April 11, 2014

Ascorbic acid, cognitive function, and Alzheimer's disease: a current review and future direction.

Gene L Bowman¹

¹Department of Neurology, CR-131, Oregon Health and Science University, Portland, OR, USA. bowmang@ohsu.edu

Biofactors (Oxford, England)

|March 16, 2012

Summary

Ascorbic acid (AA), or vitamin C, plays a role in normal brain function and Alzheimer's disease. Further research into AA

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Published on: July 29, 2018

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Last Updated: May 24, 2026

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells

Published on: April 11, 2014

Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein

Establishment of a Valuable Mimic of Alzheimer's Disease in Rat Animal Model by Intracerebroventricular Injection of Composited Amyloid Beta Protein

Published on: July 29, 2018

Area of Science:

Neuroscience
Nutritional Science
Gerontology

Background:

Ascorbic acid (AA), a vital nutrient, is investigated for its role in cognitive health.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder impacting memory and cognition.
Nutritional factors significantly influence brain aging and neurodegenerative disease progression.

Purpose of the Study:

To review human and animal studies on ascorbic acid's impact on cognitive function.
To explore the relationship between ascorbic acid and Alzheimer's disease.
To propose a framework for understanding nutrition's effect on brain aging.

Main Methods:

Narrative review of existing scientific literature.
Appraisal of human and animal research studies.
Synthesis of findings related to ascorbic acid intake, status, metabolism, and brain transport.

Main Results:

Evidence suggests ascorbic acid is implicated in normal cognitive processes.
The review examines the potential role of ascorbic acid in Alzheimer's disease pathogenesis.
A framework is presented to guide future research on nutrition and brain aging.

Conclusions:

Ascorbic acid status and metabolism are critical for healthy brain aging.
Further investigation is needed to elucidate the precise mechanisms of AA in cognition and AD.
Optimizing AA nourishment may offer therapeutic or preventative strategies for cognitive decline.