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Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

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Published on: February 16, 2022

Biomarker dynamics: estimating infection rates from serological data.

P F M Teunis¹, J C H van Eijkeren, C W Ang

¹Centre for Infectious Disease Control, Epidemiology and Surveillance Unit, RIVM, PO Box 1, 3720BA Bilthoven, The Netherlands. peter.teunis@rivm.nl

Statistics in Medicine

|March 16, 2012

Summary

Campylobacter infections are frequent, occurring annually in adults. Most infections are asymptomatic, with few leading to severe symptoms requiring notification, as shown by antibody titre analysis.

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Simultaneous Detection of Different Antibody Classes in a Multiplexed Serological Test

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Published on: July 14, 2023

Area of Science:

Epidemiology
Immunology
Biostatistics

Background:

Serum antibody titres provide insights into infection dynamics.
Understanding infection rates and antibody responses is crucial for public health.
Campylobacter infections are common, but their true incidence and asymptomatic nature require further study.

Purpose of the Study:

To develop a statistical model for analyzing serum antibody titres.
To estimate infection rates and antibody decay parameters for Campylobacter.
To assess the frequency and symptomatic burden of Campylobacter infections.

Main Methods:

Utilized a marginal distribution model for cross-sectional antibody titre data.
Employed a hierarchical dynamic model for longitudinal follow-up study data.
Applied likelihood ratio tests for homogeneity across demographic and geographic strata.

Main Results:

Developed a model linking antibody titres to infection rate, peak levels, and decay.
Estimated antibody decay halftimes: IgG (1.4 years), IgM (0.6 years), IgA (0.3 years).
Demonstrated high variability in antibody responses and consistent incidence estimates across antibody classes (IgG, IgM, IgA).

Conclusions:

Campylobacter infections are highly frequent, with high seroconversion rates suggesting near-annual occurrence in adults.
A small proportion of Campylobacter infections result in severe symptoms necessitating notification.
The study provides robust estimates of infection incidence and antibody kinetics.