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Related Experiment Video

Updated: May 24, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

Warfarin, head injury and bruising.

Marc Wallace¹, Emma D'Amato, Jasroop Chana

¹Royal Berkshire Hospital, Department of Medicine, London Road, Reading, Berkshire RG1 5AN, UK.

BMJ Case Reports

|March 16, 2012

Summary

A patient

Area of Science:

Dermatology
Cardiology

Background:

Recurrent pulmonary emboli and atrial fibrillation necessitate anticoagulation.
Warfarin therapy was interrupted due to a fall and subsequent head injury.
Facial bruising was noted after a fall, prompting a reevaluation of medication.

Purpose of the Study:

To investigate the cause of facial discoloration in a patient with recurrent pulmonary emboli.
To determine the relationship between minocycline use and the observed skin changes.
To inform the management of anticoagulation in the context of medication side effects.

Main Methods:

Clinical presentation review.
Computed tomography pulmonary angiogram.
Physical examination and patient history.

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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

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Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

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Published on: August 4, 2023

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

Medication review.

Main Results:

A new pulmonary embolus was confirmed.
Facial discoloration was present in a photosensitive distribution.
The patient had been using minocycline for acne rosacea for several years.
Minocycline-induced hyperpigmentation was diagnosed.

Conclusions:

Minocycline-induced hyperpigmentation can mimic bruising.
Accurate diagnosis of drug-induced skin changes is crucial for patient management.
Restarting warfarin was deemed appropriate after considering the diagnosis of minocycline-induced hyperpigmentation.