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Hemoglobin Hasharon and hemoglobin NYU in subjects of German origin

Berndt Zur1, Michael Ludwig, Birgit Stoffel-Wagner

  • 1Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Germany. berndt.zur@ukb.uni-bonn.de

Biochemia Medica
|March 17, 2012
PubMed

Determination of HbA1c values with high performance liquid chromatography (HPLC) occasionally reveals hemoglobin anomalies with no or minimal clinical evidence. We coincidentally detected two cases of Hb Hasharon, an alpha globin gene mutation, in two heterozygous patients and one case of Hb NYU, a delta globin gene mutation, in another patient. Both anomalies have not been described in subjects of German origin to date. Characterization was carried out with HPLC, hemoglobin electrophoresis, capillary zone electrophoresis, DNA sequencing, complete blood count and clinical chemical analysis.

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