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Updated: May 24, 2026

A Novel Rescue Technique for Difficult Intubation and Difficult Ventilation
Published on: January 17, 2011
Can we predict a difficult intubation in cleft lip/palate patients?
Isabelle Arteau-Gauthier1, Jacques E Leclerc, Audrey Godbout
1Department of Otolaryngology-Head and Neck Surgery, Laval University, Quebec, QC.
Insights
Infants with Pierre Robin sequence face a higher risk of difficult intubation. Early airway and feeding issues are key predictors in this group, alongside wider clefts in palate-only cases.
Area of Science:
- Pediatric Anesthesiology
- Craniofacial Surgery
- Neonatal Care
Background:
- Difficult intubation poses risks in infants undergoing cleft lip/palate surgery.
- Predicting intubation difficulty is crucial for patient safety and surgical planning.
Purpose of the Study:
- To identify predictors of difficult endotracheal intubation in infants with cleft lip/palate.
- To assess the impact of specific anatomical and clinical factors on intubation grade.
Main Methods:
- Retrospective review of 145 infants with cleft lip/palate.
- Evaluation of clinical and lip/palate anatomical parameters.
- Assessment of intubation grade during surgical repair.
Main Results:
- Pierre Robin sequence significantly increased intubation difficulty (23% relative risk).
- Early airway and feeding problems were strong predictors (p < .0001).
- Wider clefts in palate-only cases also predicted higher intubation grade (p = .0323).
Conclusions:
- Infants with Pierre Robin sequence have a significantly higher risk of difficult intubation.
- Early airway/feeding problems are the best predictors in Pierre Robin sequence infants.
- Cleft width is a significant predictor in infants with cleft palate but no cleft lip.
Objective:
To find predictors of a difficult intubation in infants with an isolated or a syndromic cleft lip/palate.
Study Design:
Retrospective review: single-blind trial.
Settings:
Tertiary care centre.
Methods:
A total of 145 infants born with cleft lip/palate were enrolled. Three clinical and seven lip/palate anatomic parameters were evaluated. The grade of intubation was determined by the anesthesiologist at the time of the labioplasty/staphylorrhaphy surgery at 3 and 10 months, respectively.
Main Outcome Measure:
Intubation grade.
Results:
The relative risk of a difficult intubation in the cleft lip, cleft palate without the Pierre Robin sequence, cleft lip-palate, and cleft palate with Pierre Robin sequence groups was 0, 2.7, 10, and 23%, respectively. The infants born with the Pierre Robin sequence had a statistically significant higher intubation grade. The degree of difficulty was increased in cases with early airway and feeding problems (p < .0001). Within the group of cleft palate patients without any lip malformation, a wider cleft was associated with a higher intubation grade with statistical significance (p = .0323).
Conclusions:
Infants born with Pierre Robin sequence have a statistically significantly higher risk of difficult intubation. Within this group, of all the studied factors, a clinical history of early airway and feeding problems was the best predictor of a difficult endotracheal intubation. In cleft palate patients without any cleft lip, larger width of the cleft is also a significant predictor.
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