Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...

Myocarditis III: Medical Management

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...

Myasthenia Gravis: Overview and Treatment

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...

Disorders of the Skeletal Muscle

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

Skeletal Muscle Relaxants: Adverse Effects

Skeletal Muscle Relaxants: Adverse Effects

Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cardiac autonomic function and its association with cardiometabolic disease risk factors in Black South African children.

Autonomic neuroscience : basic & clinical·2019

Same author

Short-Term High-Intensity Interval Training Is Superior to Moderate-Intensity Continuous Training in Improving Cardiac Autonomic Function in Children.

Cardiology·2018

Same author

Do Short-Term Exercise Interventions Improve Cardiometabolic Risk Factors in Children?

The Journal of pediatrics·2018

Same author

Exercise therapy for human immunodeficiency virus/AIDS patients: Guidelines for clinical exercise therapists.

Journal of exercise science and fitness·2018

Same author

Knee Osteoarthritis and the Efficacy of Kinesthesia, Balance & Agility Exercise Training: A Pilot Study.

International journal of exercise science·2016

Same author

Longitudinal patterns of change in eye-hand coordination in children aged 8-16 years.

Human movement science·2015

Search research articles

Related Experiment Video

Updated: May 24, 2026

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach

Published on: June 5, 2010

Statin therapy, myopathy and exercise--a case report.

Stuart J Semple¹

¹Department of Biokinetics & Sport Science, University of Zululand, KwaDlangezwa, South Africa. ssemple@pan.uzulu.ac.za

Lipids in Health and Disease

|March 17, 2012

Summary

Statin therapy, used for high cholesterol, may cause muscle pain (myopathy), potentially worsened by exercise. This case study observed inflammation markers during exercise before and after simvastatin treatment.

Area of Science:

Cardiology
Pharmacology
Exercise Physiology

Background:

Coronary artery disease management relies heavily on statin therapy for dyslipidemia.
Statins (HMG-CoA reductase inhibitors) effectively lower cholesterol but can cause myopathy.
Exercise's role in exacerbating statin-induced myopathy and the involvement of inflammation remain unclear.

Observation:

A patient's experience with simvastatin therapy over six months was documented.
White blood cell counts, indicating inflammation, were monitored following moderate-intensity exercise.
Exercise was performed both before and during statin treatment to compare inflammatory responses.

Findings:

The study provides insights into inflammatory responses (white cell count) during exercise in a patient on simvastatin.

More Related Videos

Application of Chronic Stimulation to Study Contractile Activity-induced Rat Skeletal Muscle Phenotypic Adaptations

Application of Chronic Stimulation to Study Contractile Activity-induced Rat Skeletal Muscle Phenotypic Adaptations

Published on: January 25, 2018

Related Experiment Videos

Last Updated: May 24, 2026

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach

Published on: June 5, 2010

Application of Chronic Stimulation to Study Contractile Activity-induced Rat Skeletal Muscle Phenotypic Adaptations

Application of Chronic Stimulation to Study Contractile Activity-induced Rat Skeletal Muscle Phenotypic Adaptations

Published on: January 25, 2018

The findings suggest a potential link between statin use, exercise, and inflammatory markers.

Implications:

Rehabilitation practitioners must be aware of potential adverse effects of statins in exercising patients.
Further research is needed to elucidate the mechanisms underlying statin-induced myopathy and exercise.
Understanding these interactions is crucial for optimizing patient care and exercise prescription.