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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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Paediatric reference values for the peripheral T cell compartment.

E J H Schatorjé1, E F A Gemen, G J A Driessen

  • 1Department of Pediatrics, Jeroen Bosch Hospital, `s-Hertogenbosch, The Netherlands.

Scandinavian Journal of Immunology
|March 17, 2012
PubMed
Summary
This summary is machine-generated.

Establishing pediatric reference values for T lymphocyte subpopulations is crucial for diagnosing immune disorders. This study provides essential data on T cell development in healthy children, aiding in disease detection.

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Area of Science:

  • Immunology
  • Pediatric Hematology
  • Flow Cytometry

Background:

  • Immunophenotyping is vital for diagnosing immunological and hematological diseases.
  • Established reference values exist for major lymphocyte populations, but not for newer T lymphocyte subsets.
  • Reliable pediatric reference values for T cell subpopulations are lacking.

Purpose of the Study:

  • To determine reference values for T lymphocyte subpopulations in healthy children.
  • To establish age-matched reference ranges for T cell subsets using the lysed whole blood method.
  • To provide a basis for diagnosing diseases indicated by deviations in T cell numbers.

Main Methods:

  • Utilized the lysed whole blood method for immunophenotyping.
  • Analyzed absolute and relative counts of T lymphocyte subpopulations.
  • Focused on healthy pediatric subjects to establish normative data.

Main Results:

  • Defined reference values for T lymphocyte subpopulations in children.
  • Observed a 1.4-fold increase in absolute T lymphocyte numbers in early infancy, followed by a threefold decrease to adult levels by 9-15 months.
  • Documented developmental patterns for recent thymic emigrants, naive cells, regulatory T cells, and CXCR5(+) helper T lymphocytes.

Conclusions:

  • The determined reference values illustrate T lymphocyte development in healthy children.
  • Deviations from these pediatric reference ranges may signify underlying diseases.
  • This data provides critical benchmarks for pediatric immunology and hematology diagnostics.