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GEFs on the RhoAd to a colossal nucleus

Ramesh A Shivdasani1

  • 1Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02215, USA. ramesh_shivdasani@dfci.harvard.edu

Developmental Cell
|March 17, 2012
PubMed
Summary

Megakaryocyte endomitosis, leading to polyploidy, involves aborted cytokinesis. This occurs due to sequential downregulation of guanine nucleotide exchange factors, GEF-H1 and ECT2, disrupting cell division regulation.

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