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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Related Experiment Video

Updated: May 24, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

Prostate cancer stem cells.

Shi-Ming Tu1, Sue-Hwa Lin

  • 1Department of Genitourinary Medical Oncology, The University of Texas, MD, Anderson Cancer Center, Houston, TX 77030-3721, USA. stu@mdanderson.org

Clinical Genitourinary Cancer
|March 17, 2012
PubMed
Summary
This summary is machine-generated.

Prostate stem cells are implicated in prostate cancer development and resistance to therapy. Understanding these stem cells could revolutionize prostate cancer research and clinical treatment strategies.

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Last Updated: May 24, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
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Published on: March 14, 2014

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Area of Science:

  • Urology
  • Cancer Biology
  • Stem Cell Research

Background:

  • Prostate gland formation involves stem cells, with regeneration observed after testosterone replacement.
  • Prostate stem cells are located in proximal ducts and the basal layer.
  • Prostate cancer shares characteristics with stem cells, including potential androgen receptor-negative status.

Purpose of the Study:

  • To review the role of stem cells in prostate cancer origin and evolution.
  • To discuss the implications of the stem cell theory of cancer for research and therapy.
  • To highlight how understanding prostate stem cells can shift clinical oncology practices.

Main Methods:

  • Review of existing literature on prostate stem cells and cancer.
  • Analysis of androgen receptor status and gene fusions (e.g., TMPRSS2-ERG) in prostate cancer.
  • Discussion of the stem cell theory of cancer and its therapeutic potential.

Main Results:

  • Prostate stem cells may be the origin of prostate cancer, explaining resistance to androgen blockade.
  • The TMPRSS2-ERG gene fusion can help identify cancer cell origins and evolution.
  • The stem cell theory offers a new framework for understanding cancer heterogeneity.

Conclusions:

  • The stem cell theory of cancer represents a potential paradigm shift in cancer research and treatment.
  • Understanding prostate stem cells is crucial for developing novel diagnostic and therapeutic strategies.
  • This approach may significantly alter the clinical management of prostate and other cancers.