Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glomerular Filtration01:15

Glomerular Filtration

The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Tight Junctions01:29

Tight Junctions

Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...
Pinocytosis00:38

Pinocytosis

Cells use energy-requiring bulk transport mechanisms to transfer large particles or large numbers of small particles into or out of the cell. The cells envelop the particles in spherical membranes called vesicles or vacuoles. Vesicles that transport material into the cell are built from the cell membrane. These vesicles encapsulate external molecules and transport them into the cell in a process called endocytosis.
Pinocytosis ("cellular drinking") is one of three main types of endocytosis. In...
Pinocytosis00:43

Pinocytosis

Cells use energy-requiring bulk transport mechanisms to transfer large particles, or large amounts of small particles, into or out of the cell. The cells envelop the particles in spherical membranes called vesicles or vacuoles. Vesicles that transport material into the cell are built from the cell membrane. These vesicles encapsulate external molecules and transport them into the cell in a process called endocytosis.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel lexicon dictionary and CNN-LSTM employed hybrid approach for sentiment detection of COVID-19 vaccines.

Scientific reports·2026
Same author

The Silent Shunt: Traumatic Splenic AV Fistula Revealed and Treated Endovascularly.

Acta medica Lituanica·2026
Same author

A Rare Case of Intraosseous Venous Malformation of Tibia in a Young Female - A Diagnostic Dilemma.

Journal of orthopaedic case reports·2025
Same author

Dual leucine zipper-bearing kinase DLK is necessary for cell autonomous regulation of insulin sensitivity.

Molecular metabolism·2025
Same author

Innovative Approach for Successful Cure of a Digital AVM With Glue and Venous Tourniquet.

Vascular and endovascular surgery·2025
Same author

From Crisis to Cure: Endovascular Management of Rasmussen Pseudoaneurysm Presenting as Life-Threatening Hemoptysis.

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists·2025
Same journal

Retraction notice to "Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR/JAK2-STAT3 pathway" [Exp. Cell Res. 361 (2017) 342-352].

Experimental cell research·2026
Same journal

METTL3-Mediated m<sup>6</sup>A Modification Stabilizes COL1A1 mRNA to Promote Extracellular Matrix Accumulation in Keloids.

Experimental cell research·2026
Same journal

Early-Life Cardiovascular Programming by Maternal Protein Restriction: Electrophysiological, Structural, and Molecular Alterations in Female Rats.

Experimental cell research·2026
Same journal

The AP2α/PDHA1 signaling pathway promotes lung cancer progression by mediating aerobic glycolysis and inhibiting cuproptosis.

Experimental cell research·2026
Same journal

Distributed transcription activity in DLX proteins defies conventional mapping of a transcription activation domain.

Experimental cell research·2026
Same journal

Extracellular release of cytotoxic aggregates from HSV-1-replicating SH-SY5Y cells: involvement of alpha-synuclein and poly-ubiquitin conjugates.

Experimental cell research·2026
See all related articles

Related Experiment Video

Updated: May 24, 2026

Generation of Patient-Derived Podocytes from Skin Biopsies
08:52

Generation of Patient-Derived Podocytes from Skin Biopsies

Published on: May 26, 2023

Podocytes: gaining a foothold.

Puneet Garg1, Lawrence B Holzman

  • 1Division of Nephrology, University of Michigan, Ann Arbor, MI, USA.

Experimental Cell Research
|March 17, 2012
PubMed
Summary
This summary is machine-generated.

Understanding glomerular disease requires studying podocyte health. This review covers recent advances in podocyte intercellular junctions, actin dynamics, cell polarity, autophagy, and mTOR biology.

More Related Videos

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
06:39

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

Related Experiment Videos

Last Updated: May 24, 2026

Generation of Patient-Derived Podocytes from Skin Biopsies
08:52

Generation of Patient-Derived Podocytes from Skin Biopsies

Published on: May 26, 2023

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation
06:39

Glomerular Outgrowth as an Ex Vivo Assay to Analyze Pathways Involved in Parietal Epithelial Cell Activation

Published on: August 19, 2020

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

Area of Science:

  • Nephrology and glomerular research.
  • Cellular biology of kidney podocytes.

Background:

  • Glomerular diseases are a significant health concern.
  • Podocyte health is crucial for kidney function.
  • Understanding podocyte development and maintenance is key.

Purpose of the Study:

  • To review recent advances in podocyte biology.
  • To focus on key mechanisms of podocyte health.
  • To provide insights into glomerular disease basis.

Main Methods:

  • Literature review of recent scientific publications.
  • Synthesis of current knowledge on podocyte function.
  • Focus on specific cellular processes.

Main Results:

  • Significant progress in understanding podocyte development.
  • Advances in maintaining podocyte health identified.
  • Key areas of focus include intercellular junctions, actin dynamics, cell polarity, autophagy, and mTOR biology.

Conclusions:

  • Recent advances offer new insights into podocyte biology.
  • These insights are crucial for understanding glomerular disease.
  • Further research in these areas holds therapeutic potential.