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Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Glomerular Filtration01:15

Glomerular Filtration

The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
Renal Drug Excretion: Glomerular Filtration01:02

Renal Drug Excretion: Glomerular Filtration

The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles.
Drug Elimination by Renal Route: Glomerular Filtration01:17

Drug Elimination by Renal Route: Glomerular Filtration

The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production takes place. A nephron has two main components: a renal corpuscle and a renal tubule. Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent...

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Related Experiment Video

Updated: May 24, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

MicroRNAs and the glomerulus.

Mitsuo Kato1, Jung Tak Park, Rama Natarajan

  • 1Department of Diabetes, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA. RNatarajan@coh.org

Experimental Cell Research
|March 17, 2012
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) regulate gene expression and are implicated in human diseases like diabetic nephropathy (DN). This review focuses on miRNA roles in the glomerulus, particularly in mesangial cells and podocytes, for potential therapeutic targets in DN.

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Micropuncture of Bowman's Space in Mice Facilitated by 2 Photon Microscopy

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Related Experiment Videos

Last Updated: May 24, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
12:21

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues

Published on: November 30, 2013

Micropuncture of Bowman's Space in Mice Facilitated by 2 Photon Microscopy
07:37

Micropuncture of Bowman's Space in Mice Facilitated by 2 Photon Microscopy

Published on: October 11, 2018

Area of Science:

  • Molecular Biology
  • Genetics
  • Nephrology

Background:

  • MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression.
  • Dysregulation of miRNAs is linked to the pathogenesis of various human diseases.
  • Diabetic nephropathy (DN) is a major cause of end-stage renal disease, characterized by glomerular hypertrophy, fibrosis, and podocyte dysfunction.

Purpose of the Study:

  • To review the biogenesis and function of miRNAs in the renal glomerulus.
  • To highlight the specific roles of miRNAs in glomerular mesangial cells and podocytes in DN pathogenesis.
  • To identify potential miRNA-based therapeutic targets for DN.

Main Methods:

  • Literature review of miRNA biogenesis and function.
  • Analysis of studies investigating miRNA expression and roles in DN.
  • Focus on glomerular cell types (mesangial cells, podocytes) in DN.

Main Results:

  • miRNAs are crucial regulators of cellular processes within the glomerulus.
  • Altered miRNA profiles are associated with DN development and progression.
  • Specific miRNAs impact mesangial cell proliferation, ECM production, and podocyte function in DN.

Conclusions:

  • Understanding miRNA mechanisms in the glomerulus is vital for advancing DN research.
  • miRNAs represent promising therapeutic targets for preventing or treating diabetic nephropathy.
  • Further investigation into glomerular miRNA functions can uncover novel strategies for kidney disease management.