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Ammonium chloride influences in vitro-neuronal network activity

Clara-Sophie Schwarz1, Stefano Ferrea, Kim Quasthoff

  • 1Department of Neurology, Heinrich-Heine University Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany. clara-sophie.schwarz@uni-duesseldorf.de

Experimental Neurology
|March 17, 2012
PubMed
Summary

Ammonia exposure in hepatic encephalopathy (HE) disrupts neuronal network activity, increasing global activity and suppressing synchrony. Blocking N-methyl-d-aspartic acid (NMDA) receptors may offer a protective strategy against these HE-related network changes.

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