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Morphea: evidence-based recommendations for treatment.

Nicole M Fett¹

¹Department of Dermatology, Perelman Center for Advanced Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. nicole.fett@uphs.upenn.edu

Indian Journal of Dermatology, Venereology and Leprology

|March 17, 2012

Summary

Morphea, a rare skin fibrosing disorder, lacks evidence-based treatments. This review offers therapeutic strategies for morphea subtypes based on current data.

Area of Science:

Dermatology
Rheumatology
Internal Medicine

Background:

Morphea is a rare fibrosing condition affecting the skin.
Current evidence-based treatment strategies for morphea are limited.

Purpose of the Study:

To review existing data on morphea treatment.
To propose therapeutic strategies tailored to specific morphea subtypes.

Main Methods:

Comprehensive literature search of Cochrane Library, Medline, and Embase until May 2011.
Included randomized controlled trials, prospective non-controlled trials, and retrospective reviews (>5 subjects).
Searched reference lists of identified articles and relevant reviews.

Main Results:

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Summarizes available treatment data for morphea.

Identifies therapeutic options based on morphea classification.

Highlights the need for further evidence-based research.

Conclusions:

Morphea treatment strategies require further development.
Subtype-specific approaches may improve therapeutic outcomes.
This review provides a foundation for evidence-based morphea management.