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Therapeutic applications of octreotide in pediatric patients

Abdulrahman Al-Hussaini1, Decker Butzner

  • 1Division of Gastroenterology, Department of Pediatrics, King Fahad Medical City, Riyadh, Saudi Arabia. aa_alhussaini@yahoo.com

Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association
|March 17, 2012
PubMed

Insights

Octreotide effectively treated pediatric gastrointestinal disorders, reducing bleeding and improving chronic diarrhea. Close monitoring is essential due to potential serious adverse events.

Area of Science:

  • Pediatric Gastroenterology
  • Clinical Pharmacology
  • Medical Therapeutics

Background:

  • Octreotide is a synthetic analog of somatostatin.
  • Its use in pediatric gastrointestinal disorders is varied.
  • This study reviews its application in a pediatric cohort.

Purpose of the Study:

  • To evaluate the efficacy and safety of octreotide.
  • To assess octreotide's role in treating diverse pediatric GI conditions.
  • To report on dosing, effectiveness, and adverse events.

Main Methods:

  • Pharmacy database search for pediatric patients receiving octreotide for GI diseases.
  • Retrospective chart review.
  • Analysis of indications, dosage, treatment outcomes, and adverse events.

Main Results:

  • Eleven patients with massive GI bleeding showed reduced transfusion needs (23 ± 9 to 8 ± 15 mL/kg, P<0.01).
  • Four patients with pancreatic pseudocyst/ascites experienced resolution.
  • Three patients with chylothorax and two with chronic diarrhea showed significant improvement; one with dumping syndrome responded rapidly. Four patients experienced adverse events, including Q-T prolongation and hyperglycemia.

Conclusions:

  • Octreotide is a valuable therapeutic option for pediatric gastroenterologists.
  • It demonstrates efficacy across a spectrum of gastrointestinal disorders.
  • Vigilant patient monitoring is crucial due to potential serious adverse events.
Abstract

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