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Updated: May 24, 2026

A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
Distraction osteogenesis for tracheostomy dependent children with severe micrognathia
Adi Rachmiel1, Samer Srouji, Omri Emodi
1Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa, Israel. adi_rach@netvision.net.il
Distraction osteogenesis successfully treated pediatric obstructive sleep apnea (OSA) in tracheostomy-dependent children by lengthening the mandible. This improved airway volume, enabling tracheostomy decannulation and resolution of OSA symptoms.
Area of Science:
- Craniofacial Surgery
- Pediatric Otolaryngology
- Sleep Medicine
Background:
- Pediatric obstructive sleep apnea (OSA) is frequently linked to congenital craniofacial malformations.
- Severe cases can cause pharyngeal airway hypoplasia, necessitating tracheostomy dependence.
Purpose of the Study:
- To evaluate the efficacy of distraction osteogenesis in improving airway dimensions and facilitating tracheostomy decannulation in pediatric OSA patients.
- To assess the long-term outcomes of mandibular lengthening in this population.
Main Methods:
- Eleven tracheostomy-dependent pediatric OSA patients (4 months to 6 years) underwent bilateral mandibular distraction osteogenesis using extraoral devices.
- Gradual distraction (1 mm/d) followed a 4-day latency period and a 10-week consolidation phase.
- 3D CT scans quantified changes in mandibular and pharyngeal airway volumes pre- and post-procedure.
Main Results:
- Mean mandibular elongation of 30 mm per side was achieved.
- Significant increases observed: mandibular volume (+29.19%) and pharyngeal airway volume (+70.53%).
- All 11 patients were decannulated within 2-3 months post-lengthening, with improved OSA symptoms and oxygen saturation (>95%).
Conclusions:
- Bilateral mandibular distraction osteogenesis is an effective technique for managing severe pediatric OSA associated with hypoplastic mandibles.
- This method successfully expands the pharyngeal airway, allowing for tracheostomy decannulation and improved respiratory function in young children.
- Long-term follow-up (mean 2.0 years) confirmed sustained positive outcomes, including normalized apnea-hypopnea index.
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