Related Experiment Video

Updated: May 24, 2026

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
06:26

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

Friable but treatable: coronary artery dissections in Ehlers-Danlos syndrome

Alexandre C Zago1, Bruno S Matte

  • 1Division of Cardiology, Hospital de Clínicas de Porto Alegre/Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. zagoac@uol.com.br

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|March 17, 2012
PubMed

Insights

Vascular Ehlers-Danlos syndrome poses challenges for coronary revascularization. This case report details successful percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) in a patient with this condition.

Area of Science:

  • Cardiology
  • Genetics
  • Vascular Surgery

Background:

  • Vascular Ehlers-Danlos syndrome (vEDS) is a rare genetic connective tissue disorder.
  • vEDS is characterized by a high risk of arterial dissection and rupture.
  • Coronary revascularization in vEDS patients presents significant challenges due to arterial friability.

Observation:

  • Percutaneous coronary intervention (PCI) carries an increased risk of dissection at stent borders due to vessel fragility and deployment pressures.
  • Coronary artery bypass graft (CABG) surgery is also complicated by the friability of vessels, including the left internal mammary artery.
  • Optimal treatment strategies for coronary artery disease in vEDS patients remain unclear, with limited published case studies.

Findings:

  • This report describes a successful PCI procedure in a 54-year-old woman with vEDS during an acute coronary syndrome episode.
  • The patient also underwent a successful CABG procedure during a separate acute coronary syndrome event.
  • Specific technical considerations during both PCI and CABG were crucial for successful outcomes in this vEDS patient.

Implications:

  • Successful PCI and CABG in vEDS patients are achievable with careful technical execution.
  • This case highlights the importance of tailored approaches to revascularization in patients with vascular Ehlers-Danlos syndrome.
  • Further case reports and studies are needed to refine optimal management strategies for coronary artery disease in vEDS.

More Related Videos

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...