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Updated: May 24, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
Shedding light on melanocyte pathobiology in vivo
M Raza Zaidi1, Edward C De Fabo, Frances P Noonan
1Laboratory of Cancer Biology & Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892-4264, USA. zaidir@mail.nih.gov
Abstract:
Cutaneous malignant melanoma is rapidly increasing in the developed world and continues to be a challenge in the clinic. Although extensive epidemiologic evidence points to solar UV as the major risk factor for melanoma, there is a significant gap in our knowledge about how this most ubiquitous environmental carcinogen interacts with the largest organ of the mammalian body (skin) at the microenvironmental and molecular level. We review some recent advances that have started to close this gap.
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