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Dorsoventral differences in intrinsic properties in developing CA1 pyramidal cells.

Béatrice Marcelin¹, Zhiqiang Liu, Yuncai Chen

¹Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1106, Marseille, F-13385 France.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|March 17, 2012

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Grid cell properties and resonance in rat hippocampal CA1 pyramidal cells show developmental and spatial gradients. These properties correlate with hyperpolarization-activated cyclic nucleotide-gated (HCN) channel currents, suggesting general organizational rules in spatial processing structures.

Area of Science:

Neuroscience
Computational Neuroscience
Cellular Electrophysiology

Background:

Entorhinal grid cell properties exhibit dorsoventral and developmental gradients, correlating with resonance and HCN channel currents.
Hippocampal CA1 pyramidal cells also display spatial and temporal gradients in their place fields.

Purpose of the Study:

To investigate the correlation between intrinsic cellular properties and HCN channel function in rat hippocampal CA1 pyramidal cells.
To determine if spatial and developmental gradients observed in entorhinal cortex grid cells are mirrored in hippocampal CA1 pyramidal cells.

Main Methods:

Electrophysiological recordings in rat hippocampal CA1 pyramidal cells across different developmental stages.
Assessment of cellular resonance properties and their modulation by cyclic adenosine monophosphate (cAMP).

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Analysis of hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channel subunit and TRIP8b expression patterns.

Main Results:

Cellular resonance was absent in the first postnatal week, emerging during the second week.
Resonance was significantly stronger in dorsal CA1 cells compared to ventral CA1 cells.
cAMP modulated resonance in ventral cells but not in dorsal cells, consistent with differential HCN channel properties.

Conclusions:

Intrinsic properties of hippocampal CA1 pyramidal cells, including resonance, exhibit spatial and developmental gradients analogous to entorhinal grid cells.
Dorsoventral differences in resonance and cAMP response are likely mediated by the differential distribution of HCN channel subunits (HCN1, HCN2) and TRIP8b.
These findings suggest conserved organizational principles across brain structures involved in environmental processing and spatial navigation.