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Acute glomerulonephritis--changing patterns in Singapore children
H K Yap1, K S Chia, B Murugasu
1Department of Paediatrics, National University of Singapore.
Pediatric Nephrology (Berlin, Germany)
|September 1, 1990
Summary
Acute glomerulonephritis (AGN) incidence in Singapore children significantly declined between 1971 and 1985. This decrease correlates with improved socioeconomic status, healthcare, and urbanization, suggesting these factors impact AGN prevalence.
Area of Science:
- Pediatrics
- Epidemiology
- Public Health
Background:
- Acute glomerulonephritis (AGN) is a kidney disease influenced by socioeconomic and environmental factors.
- A post-streptococcal aetiology was identified in over 70% of cases in a 1980-1984 sample.
- AGN affects children 12 years and under.
Purpose of the Study:
- To compare the pattern of acute glomerulonephritis (AGN) in children in 1971 versus 1985.
- To investigate the epidemiological factors contributing to changes in AGN prevalence.
Main Methods:
- Retrospective analysis of AGN cases admitted to four major pediatric departments.
- Comparison of incidence rates, age at presentation, and housing patterns between 1971 and 1985.
- Correlation with national socioeconomic indicators like GNP and urbanization.
Main Results:
- AGN admissions dropped from 411 in 1971 to 58 in 1985.
- Standardized incidence rates decreased from 0.632 to 0.023 per 1,000 children.
- Housing shifted from 31% in high-rise apartments in 1971 to 86% in 1985.
Conclusions:
- A significant decline in pediatric AGN prevalence was observed in Singapore between 1971 and 1985.
- Improvements in socioeconomic status, healthcare, and urbanization are strongly associated with this decline.
- These factors likely play a crucial role in reducing the incidence of AGN.