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Updated: May 24, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
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Published on: December 2, 2015

Depression: an inflammatory illness?

Rajeev Krishnadas1, Jonathan Cavanagh

  • 1Sackler Institute of Psychobiological Research, Institute of Health and Wellbeing, Southern General Hospital, Glasgow G51 4TF, UK. jonathan.cavanagh@glasgow.ac.uk

Journal of Neurology, Neurosurgery, and Psychiatry
|March 17, 2012
PubMed
Summary
This summary is machine-generated.

Inflammation may contribute to major depressive disorder (MDD) in vulnerable individuals. Inflammatory markers could help diagnose MDD and predict treatment outcomes for personalized therapies.

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A New Method for Inducing a Depression-Like Behavior in Rats
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An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
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07:57

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Published on: February 22, 2018

Area of Science:

  • Neuroscience
  • Psychiatry
  • Immunology

Background:

  • Major depressive disorder (MDD) is a significant health concern.
  • Emerging evidence links MDD pathophysiology to inflammatory processes.
  • Inflammation's role in MDD is subtle, not primary.

Purpose of the Study:

  • To explore the association between inflammation and MDD.
  • To investigate inflammation's potential role in MDD etiology and perpetuation.
  • To assess the utility of inflammatory markers in MDD diagnosis and treatment prediction.

Main Methods:

  • Review of preclinical and clinical findings.
  • Analysis of evidence linking peripheral inflammatory biomarkers to MDD.
  • Examination of cytokine treatment effects on depression risk.
  • Investigation of inflammatory mediators' impact on brain function.

Main Results:

  • Elevated peripheral inflammatory biomarkers observed in one-third of MDD patients.
  • Increased rates of MDD associated with inflammatory illnesses.
  • Cytokine therapy linked to higher risk of developing depression.
  • Inflammatory mediators affect neurotransmission, neurogenesis, and brain signaling.

Conclusions:

  • Inflammation may play a role in the etiology and maintenance of MDD in susceptible individuals.
  • Inflammatory markers show potential for aiding MDD diagnosis and predicting treatment response.
  • Understanding inflammation's role could lead to tailored, stratified treatments for MDD.