Related Experiment Video

Updated: May 24, 2026

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)
08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)

Published on: March 7, 2017

Pediatric cerebellar hemorrhagic glioblastoma multiforme

Peter Kalina1

  • 1Department of Radiology, Division of Neuroradiology, Mayo Clinic, 200 First Street, Rochester, MN 55905, USA.

The Open Neuroimaging Journal
|March 17, 2012
PubMed

Insights

A rare cerebellar glioblastoma multiforme (GBM) case in an 11-year-old boy presented with atypical symptoms. This pediatric brain tumor diagnosis was challenging due to minimal enhancement and hemorrhage.

Area of Science:

  • Pediatric Neuro-oncology
  • Neuroradiology
  • Neuropathology

Background:

  • Glioblastoma multiforme (GBM) is a rare primary brain tumor.
  • Cerebellar GBM is exceptionally uncommon, particularly in pediatric patients.
  • Atypical presentations of pediatric brain tumors pose diagnostic challenges.

Purpose of the Study:

  • To report a unique case of cerebellar glioblastoma multiforme in a child.
  • To highlight the diagnostic difficulties associated with atypical GBM presentations.
  • To emphasize the importance of considering rare diagnoses in pediatric neurology.

Main Methods:

  • Case report of an 11-year-old male patient.
  • Clinical evaluation including symptoms of nausea, vomiting, and ataxia.
  • Diagnostic neuroimaging with computed tomography (CT) and magnetic resonance imaging (MRI).

Main Results:

  • Imaging revealed a cerebellar mass with minimal enhancement and hemorrhage.
  • The patient's presentation included symptoms of nausea, vomiting, and ataxia.
  • The combination of cerebellar location, minimal enhancement, and hemorrhage was atypical for GBM.

Conclusions:

  • Cerebellar glioblastoma multiforme is exceedingly rare in children.
  • Atypical imaging findings, including minimal enhancement and hemorrhage, complicate the diagnosis of pediatric cerebellar GBM.
  • This case represents a previously unreported combination of findings for cerebellar GBM in a pediatric patient.

Keywords:
Glioblastoma multiformecerebellum.pediatric

More Related Videos

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma09:06

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma

Published on: November 11, 2021

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions07:39

Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions

Published on: November 17, 2021

Related Concept Videos

Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...