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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

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Endogenous endophthalmitis and liver abscesses.

S Koay¹, S Jain, I Cropley

¹Royal Free Hospital, London. s.koay@nhs.net

|March 17, 2012

Summary

A rare case of endogenous endophthalmitis, an eye infection, occurred secondary to liver abscesses in an otherwise healthy individual. Prompt antibiotic treatment led to a good visual outcome, emphasizing early diagnosis importance.

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Area of Science:

Ophthalmology
Infectious Diseases
Hepatology

Background:

Endogenous endophthalmitis is a severe intraocular infection that can lead to vision loss.
Liver abscesses are collections of pus in the liver, often caused by bacterial infections.
Streptococcus anginosus-group bacteria are known pathogens capable of causing diverse infections.

Observation:

A patient without prior medical history or immunosuppression presented with sudden, painless vision loss and malaise.
Ocular examination revealed signs consistent with endophthalmitis.
Blood cultures identified Streptococcus anginosus-constellatus bacteremia, and imaging revealed liver abscesses potentially linked to undiagnosed diverticular disease.

Findings:

The patient received prompt intravenous antibiotics targeting the identified bacteremia and subsequent management of liver abscesses.
The endophthalmitis resolved without significant visual sequelae, resulting in a favorable visual outcome.

Implications:

This case underscores the importance of considering endogenous endophthalmitis in patients with unexplained vision loss, even without typical risk factors.
Early recognition and aggressive antibiotic therapy are crucial for optimizing visual prognosis in endogenous endophthalmitis.
The potential link between diverticular disease, liver abscesses, and endogenous endophthalmitis warrants further clinical awareness.