Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epistasis01:39

Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
Epistasis Analysis01:09

Epistasis Analysis

Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated multiomic profiling reveals 2 distinct splenic marginal zone lymphoma subgroups with prognostic relevance.

Blood advances·2026
Same author

DNA methylation-based classification of hematolymphoid neoplasms.

Blood advances·2026
Same author

HDAC7 is a key factor for the germinal center reaction and its underexpression is associated with DLBCL prognosis.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

The expression of MALAT1 long non-coding RNA is associated with good prognosis in mantle cell lymphoma.

Scientific reports·2026
Same author

A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts.

European journal of immunology·2026
Same author

Increased LEF1 protein levels and isoform switching drive cell proliferation in chronic lymphocytic leukemia.

Blood·2025

Related Experiment Video

Updated: May 24, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

How epigenomics brings phenotype into being.

Jose Ignacio Martín-Subero1

  • 1Department of Anatomic Pathology, Pharmacology and Microbiology, University of Barcelona, Barcelona, Spain. imartins@clinic.ub.es

Pediatric Endocrinology Reviews : PER
|March 20, 2012
PubMed
Summary

Epigenetics explains how environmental factors influence gene function beyond DNA sequence. These epigenetic mechanisms are vital for development, disease, and inheritance, impacting phenotypes through factors like nutrition and behavior.

More Related Videos

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

Related Experiment Videos

Last Updated: May 24, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

Area of Science:

  • Biology
  • Medicine
  • Genetics

Background:

  • Genetic information alone is insufficient to explain phenotypic manifestations.
  • Gene function depends on DNA sequence interacting with environmental factors.
  • Epigenetics bridges the gap between genes and environment.

Purpose of the Study:

  • To review the critical role of epigenetics in biology and medicine.
  • To highlight epigenetic mechanisms in physiological and pathological processes.
  • To discuss environmentally induced epigenetic changes and their implications.

Main Methods:

  • Literature review of epigenetic mechanisms.
  • Summary of epigenetic roles in development and disease.
  • Discussion of environmental influences on epigenetics.

Main Results:

  • Epigenetic mechanisms (DNA methylation, histone modification) regulate key processes.
  • Environmental factors (nutrition, behavior) induce epigenetic alterations.
  • Epigenetics impacts development, tissue identity, gene transcription, and more.

Conclusions:

  • Epigenetics is crucial for understanding phenotype, development, and disease.
  • Environmental factors significantly influence epigenetic modifications.
  • Epigenetic insights are vital for medicine, inheritance, and evolution.