Radiation-induced graft copolymerization of methacrylic acid on to poly(vinyl chloride) films and their thrombogenicity
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J Singh1, A R Ray, J P Singhal
1Centre for Biomedical Engineering, Indian Institute of Technology, Delhi Hauz Khas New Delhi.
Abstract:
Methacrylic acid (MAA) was radiation grafted on to poly(vinyl chloride) (PVC) films to improve the blood compatibility of PVC. The thromobogenicity of MAA grafted PVC was evaluated by thrombus formation, platelet adhesion and haemolytic activity in vitro. The hydrophilicity of grafted PVC films was investigated by contact angle measurement. Methacrylic acid grafted PVC film showed lower thrombogenicity than that of PVC. It was found that the weight of thrombus formed on grafted PVC was less than that of PVC and glass and decreased with the increase in the graft level. The adhesion of platelets on grafted PVC was retarded after grafting with MAA hydrogels.
Insights
Radiation grafting methacrylic acid onto poly(vinyl chloride) films improves blood compatibility. The modified PVC showed reduced thrombus formation and platelet adhesion, enhancing its hemocompatibility for potential biomedical applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Surface Modification
Background:
- Poly(vinyl chloride) (PVC) is widely used but exhibits poor blood compatibility.
- Improving the hemocompatibility of PVC is crucial for biomedical device applications.
Purpose of the Study:
- To enhance the blood compatibility of poly(vinyl chloride) (PVC) films.
- To evaluate the effect of methacrylic acid (MAA) grafting on PVC's thrombogenicity and hemocompatibility.
Main Methods:
- Radiation grafting of methacrylic acid (MAA) onto poly(vinyl chloride) (PVC) films.
- In vitro evaluation of thrombogenicity: thrombus formation, platelet adhesion, and hemolytic activity.
- Contact angle measurements to assess hydrophilicity changes.
Main Results:
- Methacrylic acid grafted PVC (MAA-g-PVC) demonstrated significantly lower thrombogenicity compared to unmodified PVC and glass.
- Thrombus formation decreased with increasing MAA graft level.
- Platelet adhesion was notably reduced on MAA-g-PVC surfaces.
- Increased hydrophilicity was observed in grafted PVC films.
Conclusions:
- Radiation grafting of MAA onto PVC effectively improves its blood compatibility.
- The modified PVC exhibits reduced thrombotic potential and platelet adhesion, making it a promising candidate for blood-contacting applications.