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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
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Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
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COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Scleroderma - new aspects in pathogenesis and treatment.

Alexandra Balbir-Gurman1, Yolanda Braun-Moscovici

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PubMed
Summary

Systemic sclerosis (SSc) is a multisystem fibrotic disease. Research explores new therapies like stem cell transplantation to combat microvascular damage and fibrosis, aiming for better patient outcomes.

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Area of Science:

  • Immunology
  • Rheumatology
  • Pathology

Background:

  • Systemic sclerosis (SSc) is a multisystem disease characterized by microangiopathy, fibrosis, and autoimmune responses.
  • Pathogenesis involves immune cell activation leading to autoantibodies and pro-fibrotic mediators.
  • Fibrosis, driven by excessive collagen deposition from fibroblasts, significantly impacts prognosis.

Purpose of the Study:

  • To review the pathogenesis of Systemic Sclerosis.
  • To discuss current and emerging therapeutic strategies.
  • To highlight future research directions in SSc.

Main Methods:

  • Literature review of SSc pathogenesis and treatment.
  • Analysis of current therapeutic approaches including prostanoids, endothelin-1, and phosphodiesterase inhibitors.
  • Exploration of novel treatments like biological therapies, anti-fibrotic agents, and stem cell transplantation.

Main Results:

  • Understanding SSc pathogenesis has led to targeted treatments for pulmonary arterial hypertension and digital ulcers.
  • Biological therapies and anti-fibrotic agents are under investigation for broader SSc management.
  • Stem cell transplantation shows promise for immune system reset, fibrosis reduction, and microvasculature restoration.

Conclusions:

  • Current treatments address specific SSc manifestations, but broader therapeutic options are needed.
  • Emerging therapies, including stem cell transplantation, offer potential for disease modification.
  • Future research should focus on genetic factors, biomarkers, and targeted drug development for SSc.