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Neurologic and other systemic manifestations in FMF: published and own experience

O Feld1, G Yahalom, A Livneh

  • 1FMF Clinic and Department of Medicine F, Sheba Medical Center, Ramat Gan, Tel-Hashomer 52621, Israel. Feld.family@gmail.com

Best Practice & Research. Clinical Rheumatology
|March 20, 2012
PubMed
Abstract

Insights

Familial Mediterranean fever (FMF) can cause diverse neurological issues, some directly linked to the disease or its treatment. Awareness of these potential FMF-related neurological manifestations is crucial for patient care.

Area of Science:

  • Rheumatology and Neurology
  • Autoinflammatory Diseases
  • Genetic Disorders

Background:

  • Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory condition characterized by recurrent fever and polyserositis.
  • Neurologic involvement in FMF is infrequently observed and often presumed to be coincidental.
  • Understanding the spectrum of neurological manifestations in FMF is essential for comprehensive patient management.

Purpose of the Study:

  • To comprehensively review the range of neurological manifestations associated with Familial Mediterranean fever (FMF).
  • To determine the relationship between these neurological symptoms and FMF, its complications, comorbidities, or treatment side effects.

Main Methods:

  • Systematic literature review using PubMed to identify reported neurologic manifestations in FMF patients.
  • Inclusion of data from a large FMF registry (12,000 patients) and Sheba Medical Center's database.
  • Analysis of identified neurologic events for their potential association with FMF.

Main Results:

  • A broad spectrum of neurologic manifestations was observed in patients with FMF.
  • A significant proportion of these manifestations were found to be directly related to FMF, its complications, associated diseases, or adverse treatment effects.
  • Some neurologic manifestations were identified as incidental or had an uncertain link to FMF.

Conclusions:

  • Physicians managing FMF patients must be vigilant regarding potential neurologic manifestations and their underlying causes.
  • This review provides critical insights into the complex association between FMF and neurological disorders.
  • Enhanced awareness can lead to improved diagnosis and management strategies for FMF patients experiencing neurological symptoms.

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