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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...

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Related Experiment Video

Updated: May 24, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Psoriatic arthritis.

Gleison Vieira Duarte1, César Faillace, Jozélio Freire de Carvalho

  • 1Dermatology Division, Oncology Clinic, Salvador, Bahia, Brazil.

Best Practice & Research. Clinical Rheumatology
|March 20, 2012
PubMed
Summary

Psoriatic arthritis (PsA) is a chronic inflammatory condition linked to psoriasis, impacting quality of life and potentially leading to severe joint damage. Treatment focuses on symptom relief and preventing disease progression.

Area of Science:

  • Rheumatology
  • Immunology
  • Dermatology

Background:

  • Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis.
  • Its exact prevalence and pathogenesis remain unclear, with genetic, environmental, and immunologic factors implicated.
  • PsA can manifest before, after, or concurrently with skin lesions.

Purpose of the Study:

  • To summarize the understanding of psoriatic arthritis (PsA).
  • To outline the goals of PsA treatment.
  • To describe treatment selection criteria based on disease severity.

Main Methods:

  • Review of existing literature on psoriatic arthritis.
  • Analysis of factors contributing to PsA development.
  • Evaluation of treatment strategies for PsA.

Related Experiment Videos

Last Updated: May 24, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Main Results:

  • PsA significantly impacts patient quality of life and functional capacity.
  • A subset of patients (up to 20%) develops destructive forms of the disease.
  • PsA is linked to increased mortality rates.

Conclusions:

  • PsA management aims to alleviate symptoms, prevent joint damage, and improve survival.
  • Treatment choice is guided by clinical presentation severity.
  • Immunobiological agents are reserved for patients unresponsive to conservative therapies.