Related Experiment Video
Updated: May 24, 2026
Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
Published on: May 24, 2021
Assessment of left ventricular ejection fraction using the wall motion score index in cardiac magnetic resonance
Réal Lebeau1, Karim Serri, Marie-Claude Morice
1Hôpital du Sacré-Coeur de Montréal, université de Montréal, Canada. real.lebeau@yahoo.ca
Background:
Left ventricular ejection fraction (LVEF) is an important indicator of left ventricular function and of the severity and prognosis of ischaemic heart disease. Assessment of regional function using the wall motion score index (WMSI) is an alternative means of evaluating left ventricular function.
Aim:
We attempted to evaluate LVEF by a method using the WMSI with cardiac magnetic resonance imaging (MRI).
Methods:
One hundred and twenty-two patients referred for evaluation of heart disease had rest WMSI evaluation by cardiac MRI. The WMSI was evaluated using the 16-segment model and score proposed by the American Society of Echocardiography. In our first group of 80 patients, a correlation between WMSI and cardiac MRI LVEF was established and a regression equation was derived. This regression equation was then used in 42 consecutive patients to compare WMSI LVEF with the gold standard MRI LVEF.
Results:
In the first 80 patients, MRI LVEF and WMSI correlated very well (r=0.93). Similarly, in the second group of 42 patients, WMSI LVEF derived from the regression equation correlated very well with MRI LVEF (r=0.94).
Conclusion:
An objective evaluation of LVEF can be easily made using the WMSI with cardiac MRI, which correlates very well with standard MRI planimetric methods.
