Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

EDRF in intact vascular networks.

T M Griffith1, D H Edwards

  • 1Department of Diagnostic Radiology, University of Wales College of Medicine, Cardiff, UK.

Blood Vessels
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure.

American journal of physiology. Cell physiology·2015
Same author

Molecular and epidemiological analysis of methicillin-resistant Staphylococcus aureus otorrhoea: hospital- or community-acquired?

The Journal of laryngology and otology·2010
Same author

Neuromechanical simulation of the locust jump.

The Journal of experimental biology·2010
Same author

Dynamics of a three-variable nonlinear model of vasomotion: comparison of theory and experiment.

Biophysical journal·2007
Same author

The Bacillus subtilis DivIVA protein has a sporulation-specific proximity to Spo0J.

Journal of bacteriology·2006
Same author

Stress avoidance in a common annual: reproductive timing is important for local adaptation and geographic distribution.

Journal of evolutionary biology·2005

Endothelial-derived relaxing factor (EDRF) normally suppresses a constrictor response in rabbit ear arteries, preventing flow autoregulation. EDRF also optimizes artery branching for efficient blood flow and reduced cardiac workload.

Area of Science:

  • Physiology
  • Vascular Biology
  • Microcirculation

Background:

  • Basal endothelial-derived relaxing factor (EDRF) activity plays a crucial role in regulating vascular tone and blood flow.
  • Understanding EDRF's influence on resistance arteries is vital for comprehending cardiovascular autoregulation and hemodynamics.

Purpose of the Study:

  • To investigate the role of basal EDRF activity in regulating vascular tone and flow autoregulation in isolated rabbit ear resistance arteries.
  • To examine how EDRF influences the geometrical optimality of resistance artery branching patterns.

Main Methods:

  • X-ray microangiography was employed to measure changes in arterial diameter and perfusion pressure.
  • Rabbit ear preparations were perfused under controlled-pressure and controlled-flow conditions.

Related Experiment Videos

  • Pharmacological agents like hemoglobin and L-NMMA were used to inhibit EDRF activity.

    • Main Results:

    • Flow autoregulation was observed only when EDRF activity was inhibited, indicating EDRF normally suppresses a constrictor response.
    • This flow-dependent constrictor response is mediated by flow and/or pressure, and is normally suppressed by EDRF.
    • Basal EDRF activity was found to maintain geometrical optimality (minimum volume and power losses) in artery branching.

    Conclusions:

    • EDRF activity is essential for suppressing a constrictor response, thereby preventing flow autoregulation in rabbit ear arteries under certain conditions.
    • EDRF contributes to efficient blood flow dynamics by optimizing resistance artery branching, potentially minimizing cardiac work.