Related Experiment Video
Updated: May 24, 2026

Green Synthesis of Quinoline-Based Ionic Liquid
Published on: September 27, 2024
Design and synthesis of novel magnolol derivatives as potential antimicrobial and antiproliferative compounds
Srinivas Jada1, Mahendhar Reddy Doma, Parvinder Pal Singh
1Organic Division-I, Indian Institute of Chemical Technology, Hyderabad 500007, India.
Abstract:
A series of novel magnolol derivatives were synthesised and evaluated for in vitro antimicrobial and antiproliferative activities. We found that most of the compounds were effective inhibitors of Staphylococcus aureus, MRSA and VRE with MIC in the range of 1-64 μg/mL and MBC in the range of 1-128 μg/mL. Few derivatives also exhibited promising antifungal activity. Some magnolol analogues exhibited promising antiproliferative activity than parent magnolol when tested against three human cancer cell lines.
Related Concept Videos
Antifungal Agents
Inhibitors of Bacterial DNA Synthesis
Inhibitors of Gram-positive Cell Wall Synthesis
Inhibitors of Bacterial Protein Synthesis
Antianginal Drugs: Calcium Channel Blockers and Ranolazine
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
Combined Effects of Drugs: Synergism
Such synergistic combinations...