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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Related Experiment Video

Updated: May 24, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Published on: May 14, 2016

p62: a versatile multitasker takes on cancer.

Jorge Moscat¹, Maria T Diaz-Meco

¹Sanford-Burnham Medical Research Institute, 10901N. Torrey Pines Road, La Jolla, CA 92037, USA. jmoscat@sanfordburnham.org

Trends in Biochemical Sciences

|March 20, 2012

Summary

The protein p62 is vital for cancer development. It regulates nutrient sensing, autophagy, and genomic stability, making it a key target for cancer research.

Area of Science:

Molecular Biology
Cellular Biology
Cancer Research

Background:

p62, initially identified as a protein kinase C (PKC)-interacting protein, is a multifunctional signaling molecule.
Its interactions with key signaling components underpin its diverse cellular roles.

Purpose of the Study:

To elucidate the multifaceted roles of p62 in cellular functions.
To understand p62's contribution to tumor transformation and cancer progression.

Main Methods:

The study reviews existing literature on p62's functions.
Analysis of p62's interactions with signaling pathways involved in cell growth and cancer.

Main Results:

p62 is essential for tumor transformation.

Related Experiment Videos

Last Updated: May 24, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Published on: May 14, 2016

It acts as a key regulator in nutrient sensing, autophagy, and oxidative stress response.

p62 modulates cell division and maintains genomic stability.

Conclusions:

p62 is a critical mediator in cellular processes crucial for cancer development.
Its roles in nutrient sensing, autophagy, and genomic stability highlight its significance in cancer biology.