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Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

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The relationship between glucose excursion and cognitive function in aged type 2 diabetes patients.

Yuan Zhong¹, Xiao Yan Zhang, Ya Miao

¹Department of Geriatrics, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.

Biomedical and Environmental Sciences : BES

|March 20, 2012

Summary

High glucose excursion in older adults with type 2 diabetes is linked to poorer cognitive function. Controlling glucose variability may help preserve cognitive health in this population.

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Area of Science:

Endocrinology
Neuroscience
Geriatrics

Background:

Type 2 diabetes (T2DM) is linked to increased dementia risk.
Glucose variability is an independent risk factor for diabetic complications.

Purpose of the Study:

To investigate the relationship between glucose excursion and cognitive function in aged T2DM patients.

Main Methods:

248 aged T2DM patients used continuous glucose monitoring (CGMS) for 3 days.
Evaluated glucose excursion using mean amplitude of glycemic excursions (MAGE) and mean of daily difference (MODD).
Assessed cognitive function with tests including the mini-mental status examination (MMSE).

Main Results:

MAGE and MODD showed negative correlations with MMSE scores.
Multivariate regression confirmed MAGE and MODD negatively impacted MMSE, independent of other factors.
Elevated glucose excursion was associated with lower general cognitive function.

Conclusions:

Glucose excursion significantly relates to cognitive function in older T2DM patients.
Higher glucose excursion correlates with decreased MMSE scores.
Therapies targeting glucose excursion control may benefit cognitive function in aged T2DM patients.