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Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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Related Experiment Video

Updated: May 24, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Headaches related to psychoactive substance use.

Yeşim Yetimalar Beckmann¹, Mustafa Seçkin, Ali İlhan Manavgat

¹Department of Neurology, Atatürk Training and Research Hospital, İzmir, Turkey. ybeckmann@gmail.com

Clinical Neurology and Neurosurgery

|March 20, 2012

Summary

Headache is common in psychoactive substance abusers, with most experiencing it after starting substance use. Migraine prevalence was higher in this group, yet most did not seek medical help.

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Area of Science:

Neuroscience
Addiction Medicine
Public Health

Background:

Headache is a common neurological symptom.
Psychoactive substance use is a significant public health concern with various associated health issues.

Purpose of the Study:

To investigate the association between headache and psychoactive substance use.
To determine the prevalence of headache in individuals with substance use disorders.

Main Methods:

A cohort of 1015 psychoactive substance abusers completed a detailed headache questionnaire.
Data on substance use patterns and headache characteristics were collected.

Main Results:

The prevalence of headache among substance abusers was 26.9%.
Headache attributed to substance use or withdrawal occurred in 18% of patients.
Migraine was more prevalent in abusers than in the general population, and 78% of headache patients did not seek medical help.

Conclusions:

A potential link exists between headache and psychoactive substance use, as 94.5% of users reported headaches after substance initiation.
Cannabis use, particularly earlier onset and longer duration, correlated with higher headache incidence.
The high prevalence of headache and underutilization of medical care highlight a need for integrated treatment approaches.