Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Choroid plexus cysts and chromosomal defects.

J G Thorpe-Beeston1, C M Gosden, K H Nicolaides

  • 1Harris Birthright Research Centre for Fetal Medicine, Department of Obstetrics and Gynaecology, King's College Hospital of Medicine and Dentistry, Denmark Hill, London.

The British Journal of Radiology
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The outcome of pregnancies in women with cystic fibrosis--single centre experience 1998-2011.

BJOG : an international journal of obstetrics and gynaecology·2012
Same author

Contraception and pregnancy in cystic fibrosis.

Journal of the Royal Society of Medicine·2009
Same author

WITHDRAWN: Chorion villus sampling versus amniocentesis for prenatal diagnosis.

The Cochrane database of systematic reviews·2007
Same author

Spontaneous expulsion of submucous fibroid after preterm labour.

BJOG : an international journal of obstetrics and gynaecology·2002
Same author

Trial of vaginal delivery following three previous caesarean sections.

BJOG : an international journal of obstetrics and gynaecology·2002
Same author

Chorion villus sampling versus amniocentesis for prenatal diagnosis.

The Cochrane database of systematic reviews·2000
Same journal

Machine learning models using 18F-FDG PET/CT radiomics for RAS mutation prediction and prognostic stratification in colorectal cancer.

The British journal of radiology·2026
Same journal

Predictors of Relapse in Oligometastatic Prostate Patients Receiving Stereotactic Ablative Radiotherapy.

The British journal of radiology·2026
Same journal

An Evaluation of Radiotherapy and Response in the Management of Perivascular Epithelioid Cell Tumors.

The British journal of radiology·2026
Same journal

Ensuring radiology reporting quality across a national lung cancer screening programme.

The British journal of radiology·2026
Same journal

Utility of High-Resolution Semiconductor Positron Emission Tomography/Computed Tomography in the Assessment of Breast Cancer Extent: Comparison with Magnetic Resonance Imaging.

The British journal of radiology·2026
Same journal

Airway Imaging Practices in Primary Ciliary Dyskinesia: A Global Survey to Guide Standardized Guidelines.

The British journal of radiology·2026
See all related articles

Fetal choroid plexus cysts in 83 pregnancies were studied. Abnormal karyotypes, including trisomy 18, were found in 20 fetuses, often with other structural malformations.

Area of Science:

  • Prenatal diagnosis
  • Fetal medicine
  • Genetics

Background:

  • Choroid plexus cysts are common findings during fetal ultrasounds.
  • Their association with chromosomal abnormalities requires further investigation.
  • Understanding this association aids in risk assessment and genetic counseling.

Purpose of the Study:

  • To investigate the incidence of abnormal karyotypes in fetuses presenting with choroid plexus cysts.
  • To identify specific chromosomal abnormalities associated with these cysts.
  • To determine the correlation between choroid plexus cysts, karyotype abnormalities, and other fetal malformations.

Main Methods:

  • Retrospective analysis of 83 pregnant women with fetal choroid plexus cysts over a 4-year period.
  • Karyotyping was performed on fetuses with suspected chromosomal abnormalities.

Related Experiment Videos

  • Ultrasound examinations documented the presence and type of choroid plexus cysts and other structural malformations.

    • Main Results:

    • Abnormal karyotypes were detected in 20 out of 83 fetuses (24%).
    • The most frequent abnormality was trisomy 18 (16 cases), followed by trisomy 13 (1 case), triploidy (1 case), and translocation Down's syndrome (2 cases).
    • All fetuses with chromosomal defects exhibited structural malformations in addition to choroid plexus cysts.

    Conclusions:

    • Fetal choroid plexus cysts are associated with a significant rate of chromosomal abnormalities, particularly trisomy 18.
    • The presence of choroid plexus cysts alongside other structural malformations increases the suspicion of aneuploidy.
    • These findings underscore the importance of comprehensive fetal assessment and genetic evaluation in cases of isolated or complex choroid plexus cysts.