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Updated: May 24, 2026

Quantitative Analysis of the Cellular Lipidome of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry
Published on: March 8, 2020
Analysis of cycloserine and related compounds using aqueous normal phase chromatography/mass spectrometry
Joseph J Pesek1, Maria T Matyska, Andy Dang
1Department of Chemistry, San Jose State University, San Jose, CA 95192, USA. joseph.pesek@sjsu.edu
Abstract:
A new approach is evaluated for the analysis of cycloserine, a strongly hydrophilic drug. The method utilized is aqueous normal phase chromatography with a silica hydride-based stationary phase and mass spectrometry for detection. The samples are analyzed to determine the number of components and they are identified when possible. In addition, the composition change is monitored with respect to time and sample solvent. Analyses using both gradient and isocratic conditions are presented. The repeatability of inter- and intraday analyses is also determined.
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